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Chemotaxis is the ability of certain microscopic organisms to sense and swim towards beneficial or away from detrimental chemicals in their surroundings. Identifying this behavior is important for understanding the relationships between species and their environments in the natural world. Predicting migration of an entire population from known characteristics of individual microorganisms is a key contribution, but can be a laborious process and requires watching and waiting for visual evidence of the process on a large population scale. Sonification offers a novel solution to this problem by allowing the observer to tap into our auditory sensory system to process information. In this project, we developed and assessed a proof-of-concept sonification tool as a high throughput, real-time screening tool for chemotaxis in populations of swimming bacteria. The tool operates by reporting the y-axis position of bacteria that appear in the microscope image as microsecond duration pitched notes, giving the user a sense of the average location of the population. In this paper, we present how it has been used as a chemotaxis assay and as a tool to locate traveling waves of bacteria as they pass through the field of view in order to capture data at specific timepoints, which is used to analyze individual swimming patterns of microorganisms within the wave. 

Abstract Sonification, or the practice of generating sound from data, is a promising alternative or complement to data visualization for exploring research questions in the life sciences. Expressing or communicating data in the form of sound rather than graphs, tables, or renderings can provide a secondary information source for multitasking or remote monitoring purposes or make data accessible when visualizations cannot be used. While popular in astronomy, neuroscience, and geophysics as a technique for data exploration and communication, its potential in the biological and biotechnological sciences has not been fully explored. In this review, we introduce sonification as a concept, some examples of how sonification has been used to address areas of interest in biology, and the history of the technique. We then highlight a selection of biology‐related publications that involve sonifications of DNA datasets and protein datasets, sonifications for data collection and interpretation, and sonifications aimed to improve science communication and accessibility. Through this review, we aim to show how sonification has been used both as a discovery tool and a communication tool and to inspire more life‐science researchers to incorporate sonification into their own studies.